Lyme Disease

Everything you need to know about Lyme Disease and Borrelia - symptoms, causes, treatment options available in Australia

Dr. Louis J Sisk
Dr. Louis J Sisk
BSc(Hons) MBChB MRCS(Glasg) MTrauma
August 23, 2025
6 min read

What You Need to Know - The Basics

Borrelia bacteria can make you sick if you're bitten by an infected tick.

The main things to know:

  • You might get a rash that looks like a bullseye.
  • You could feel very tired, get headaches, or have sore muscles and joints.
  • Anyone can get it, but people who spend time in bushy or grassy areas are more at risk.
  • It's important to treat it early to avoid serious problems.

When to see a doctor immediately: If you notice a bullseye rash or have a fever after a tick bite.

Doctors can help you feel better with the right treatment.


Overview

Borrelia is a genus of bacteria known to cause Lyme disease, a condition characterised by a range of symptoms that can affect multiple systems in the body, including the skin, joints, heart, and nervous system. The pathophysiology of Borrelia involves complex interactions between the bacteria and the host's immune system. Once transmitted through the bite of an infected tick, Borrelia spirochetes disseminate through the bloodstream, potentially leading to widespread infection if not promptly treated [1].

The disease mechanisms involve the bacteria's ability to evade the immune response, often leading to persistent infection. Borrelia can alter its surface proteins, making it difficult for the immune system to recognise and eliminate the pathogen. This evasion strategy contributes to the chronic nature of the disease in some individuals [2].


Statistics and Prevalence in Australia

In Australia, the prevalence of Borrelia and Lyme disease-like illnesses is not officially tracked by major health agencies such as the Australian Bureau of Statistics (ABS) or the Australian Institute of Health and Welfare (AIHW) [2][3]. The Lyme Disease Association of Australia estimates an annual incidence of 0.09%, based on patient reports and population statistics, though this figure is not officially recognised by government health agencies [2].


Symptoms and Clinical Presentation

The clinical presentation of Borrelia infection can vary significantly. Early symptoms often include erythema migrans, a distinctive rash that appears at the site of the tick bite. This rash is considered pathognomonic for Lyme disease and is a critical diagnostic indicator [1]. Other early symptoms may include fever, chills, headache, fatigue, and muscle and joint aches.

As the disease progresses, patients may experience more severe manifestations such as arthritis, neurological symptoms (including facial palsy and meningitis), and cardiac issues like heart block [2]. It is crucial for healthcare providers to recognise red flag symptoms that require immediate attention, such as severe headaches, neck stiffness, and palpitations, which may indicate complications [3].


Causes and Risk Factors

Borrelia infection is primarily transmitted through the bite of infected Ixodes ticks, commonly known as deer ticks or black-legged ticks. The risk of infection is higher in areas where these ticks are prevalent, although there is currently no robust evidence of endemic Lyme borreliosis in Australia [2]. Travellers returning from Lyme-endemic regions overseas are at increased risk [3].

Risk factors for Borrelia infection include outdoor activities in wooded or grassy areas where ticks are common, inadequate use of protective clothing, and failure to use tick repellents. Individuals with compromised immune systems may also be at higher risk of developing severe disease [1].


Diagnosis

The diagnosis of Borrelia infection in Australia follows a two-tier serological testing protocol. Initially, an enzyme-linked immunosorbent assay (ELISA) is used to screen for antibodies against Borrelia. If the ELISA is positive, a confirmatory Western blot test is performed [2]. It is essential that these tests are conducted in laboratories accredited by the National Association of Testing Authorities (NATA) or the Royal College of Pathologists of Australasia (RCPA) to ensure accuracy [3].

In cases where the characteristic erythema migrans rash is present, laboratory confirmation may not be necessary for diagnosis. However, for atypical presentations or in the absence of a rash, serological testing is crucial [2].


Treatment Options in Australia

Treatment for Borrelia infection in Australia is guided by clinical practice guidelines, which recommend short courses of antibiotics following laboratory confirmation of the disease. Commonly prescribed antibiotics include doxycycline, amoxicillin, and cefuroxime axetil [2]. Prolonged or combination antibiotic regimens are not supported by current evidence and are generally discouraged [3].

The Medicare Benefits Schedule (MBS) provides coverage for diagnostic testing and treatment of Borrelia infection, ensuring that patients have access to necessary healthcare services. However, it is important for patients to consult with healthcare providers to understand their specific entitlements [2].


Living with Borrelia

Managing Borrelia infection involves regular monitoring and follow-up care to ensure the resolution of symptoms and prevent complications. Patient education is a critical component of management, empowering individuals to recognise symptoms and seek timely medical attention [1].

Managing this condition is an ongoing process, but many people learn to live well with proper support and care.

Daily management:

  • Follow your treatment plan as prescribed
  • Keep track of your symptoms and how you're feeling
  • Stay in regular contact with your healthcare team
  • Learn about your condition so you can make informed decisions

Building your support network:

  • Talk to family and friends about your condition
  • Consider joining support groups
  • Work with healthcare professionals who understand your needs
  • Don't hesitate to ask for help when you need it

Self-care strategies:

  • Maintain healthy lifestyle habits where possible
  • Manage stress and get adequate rest
  • Stay as active as your condition allows
  • Focus on activities and relationships that bring you joy

Important: With proper management and support, many people with this condition live full and active lives.

Self-management strategies, such as maintaining a healthy lifestyle, adhering to prescribed treatments, and engaging in regular physical activity, can help optimise quality of life.

Psychosocial support may also be beneficial for patients experiencing chronic symptoms or significant lifestyle disruptions due to the disease [2].


Prevention

Preventing Borrelia infection involves strategies to reduce exposure to ticks. These include wearing protective clothing, using insect repellents, performing regular tick checks after outdoor activities, and promptly removing any attached ticks [1]. Public health education campaigns can play a vital role in raising awareness about tick-borne diseases and promoting preventive measures [2].


Key Takeaways

• Borrelia is a medical condition that can be effectively managed with proper diagnosis and treatment from healthcare professionals. • Treatment options are available in Australia through Medicare and PBS, making care accessible and affordable for most people. • Early detection and appropriate management can significantly improve outcomes and quality of life for people with this condition.


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  • Fever - Understanding fever causes and when to seek treatment
  • Chickenpox - Managing chickenpox symptoms and prevention

References

  1. Research and guidelines, Australian Parliament
  2. Source: www1.health.gov.au
  3. DSCATT Clinical Pathway Draft, Department of Health (PDF, July 2024)